Rheumatoid Arthritis by the Numbers: Facts and Statistics


rheumatoid arthritis facts

Rheumatoid Arthritis Facts and Statistics

Rheumatoid arthritis (RA) is one of the most common forms of arthritis. It can affect anyone of any age or background.

RA affects 1.3 million American adults, this according to the American College of Rheumatology. Worldwide, RA prevalence is up to 1%, this according to the World Health Organization (WHO).

Prevalence of RA

Age and Gender

The average onset of RA is between the ages of 30 and 60, but RA can strike at any age. Even children can develop the disease. According to the Mayo Clinic, the lifetime risk of developing RA is 3.6% for women and 1.7% for men.

Women tend to develop RA much earlier in life, during their 30s and 40s. The course of the disease also differs between the genders.

Research shows women report more symptoms than men and their symptoms tend to be worse. Further, women may not respond to treatment as well as men do.

If you are a woman with RA, you are less likely to achieve remission, which is a period where you no longer experience symptoms and pain.

Women with RA may also develop fibromyalgia, which makes RA symptoms even worse. In fact, 5%-20% of people with RA also have fibromyalgia, this according to researchers from The Royal Wolverhampton Hospital, Wolverhampton, United Kingdom.

Researchers think hormones play a role in the development of RA, which may explain as to why more women are affected. Women tend to develop the disease at times when their hormones are unstable, such as after pregnancy or around menopause.

RA in Children and Older Adults

According to the Arthritis Foundation, at least 300,000 children under the age of 16 have arthritis or a rheumatic condition. Just like adult RA, juvenile rheumatoid arthritis (JRA) is caused by the immune system attacking its healthy tissues because it perceives them as foreign invaders.

Researchers believe children with JRA have the same genetic triggers as adults in the development of JRA. Moreover, children with JRA experience some of the same symptoms seen in adult RA.

The prevalence of RA in adults over age 60 is 2%. Treating RA in the elderly population can be challenging.

One of the problems older adults with RA face is sensitivity to RA medications. Taking other medications and having other diseases can also result in drug interactions, medication side effects, and even an advanced form of the disease.

Race and Ethnicity

RA does affect certain races and ethnicities more than others – not just in prevalence, but also in disease severity.

One report from Arthritis Research & Therapy finds Native Americans are at the highest risk for developing RA, which is up to 4 times higher than Europeans.   Genetic factors are likely to blame for higher incidences related to race and ethnicity.

People of Afro-Caribbean origin are at the lowest for developing RA. In the United States, African Americans, European-Americans and Chinese Americans appear to have lower incidences of RA while those of South African origin tend to have higher RA incidence rates.

One 2013 report in the American Journal of Medicine finds significant differences in disease activity across ethnic and racial groups, with the lowest levels of disease activity in whites. Moreover, remission rates are highest in whites and lowest in African Americans.

Globally, the highest mortality rates associated with RA are in are the African Continent. The countries with the highest rates of RA are in Europe, with Finland having the most cases of RA.

Next page: Learn about the risk factors of RA and what you can do to decrease your risk.

Risk Factors of RA

Experts don’t know what causes RA, but research seems to suggest that you are at a higher risk for developing RA if you are:

  • Genetically disposed to RA
  • Exposed to harmful chemicals, including smoking
  • Experienced significant hormonal imbalances
  • An imbalance of intestinal microbes, resulting from infection or other illness

Genetics

The genetics involved in the development of RA are complex, but from what researchers know, heritability increases your risk for RA by 60% and a having an HLA gene (one genetic risk factor for RA) increases your risk from 11 to 37%, this according to a 2013 report in Clinical Reviews in Allergy & Immunology.

While having a close family member with RA increases your risk, RA is not an inherited disease, your predisposition to it is.

Smoking

An exact link between nicotine and RA is unknown, but researchers confirm prolonged smoking can lead to an increased rheumatoid factor, the main antibody (protein) responsible for the development of RA. The presence of a rheumatoid factor indicates your immune system is not functioning properly.

One 2013 study published in Arthritis Research and Therapy finds that even light smoking can increase your risk for RA. Moreover, a woman’s risk is doubled by smoking.

If you quit smoking, your chances of developing RA decrease and continue to decrease over time. Smoking is also associated with higher disease activity and quitting can improve symptoms and reduce your risk for complications.

Hormonal Imbalances

The fact more women get RA suggests hormones are at play in the development of the disease. The idea is supported by the idea that RA gets better during pregnancy and worsens following childbirth.

There is also evidence that irregular periods and early menopause may increase a women’s risk of developing RA. Researchers also think natural hormone fluctuations, hormone medications, and birth control are additional disease triggers.

Testosterone

Low testosterone levels in men may also increase the risk for the development of RA later in life, this according to researchers from the Lund University in Sweden.

Infections and Microbe Imbalances

In recent years, researchers have been looking at connections between bacterial and viral infections and development of RA. Many believe specific infections may be linked to RA, including chronic hepatitis C and gingivitis.

Moreover, a person’s microbes (good and bad microorganisms located throughout the body) may promote the development of RA.

More research is needed to confirm any specific connections between infection, microbes and RA development.

Disease Severity

The same risk factors for RA also affect the severity of the disease. Doctors access the severity of the disease as mild, moderate or severe.

Your doctor will determine disease severity based on:

  • How active the disease is
  • How much functional impairment there is
  • Any physical damage

There is little research and clinical evidence on disease severity types and prevalence of severity types. It seems, however, the worst cases of RA are in people who have a progressive and more severe form of the disease.

Progressive RA advances and causes persistent inflammation and worsening pain. It requires aggressive treatment and is largely dependent on it the risk factors leading to the development of the disease.

Next page: What are the complications of RA? Continue to learn more about what this means for you.

What Are the Complications of RA?

RA increases your risk for more serious conditions, including heart disease and stroke. In fact, the risk of cardiac death is up 50% higher for people with RA, compared to the rest of the population.

RA patients are also hospitalized at a greater rate than people without RA.

One 2013 report from the Mayo Clinic looked at 799 patients with RA and 797 patients without RA in Olmsted County, Minnesota. The patients with RA experienced 2968 hospitalizations while those without it experienced 2069 hospitalizations.

The RA patients in the Mayo Clinic study were mostly hospitalized for depression and diabetes at much higher rates than patients who had these conditions, but not RA. There were no differences amongst the sexes, specific age groups, or based on the time of the year.

Disease activity appeared to play a role in the higher rates of hospitalization, as people with severe RA tend to have more complications.

Life Expectancy

RA isn’t fatal, but its complications can shorten your life. Infection deaths are more common in people with RA at 36%, compared to the 26% of people without RA, this according to researchers from Helsinki University Central Hospital in Finland.

Disease progress and severity vary from person to person. People with specific disease factors will have a more progressive and severe form of RA, while those that do not have these factors will have a mild to moderate form of the disease.

Many people are living with RA who are in their 80s and 90s, so having RA doesn’t necessarily mean you won’t have a long life. It means you need to work with your doctor to treat RA aggressively and make healthy lifestyle choices (eating well, exercising, avoiding smoking, etc.) to avoid complications that may affect your quality of life or shorten it.

Remission

Current research data shows drug-free remission from RA ranges from 3.6 to 22 %. Certain factors increase your chances of remission, including having a milder form of the disease, early diagnosis, and aggressive treatment.

Men seem to have higher remission rates than women. One study from 2012 reported in Arthritis Care & Research found men have a 38% higher chance of remission than women and can sustain that during the first two years.

What Does All This Mean for You?

Currently, there is no cure for RA. There have been many advances in the last 30 years for treating RA, but none of them will cure you.

The goal of RA treatment is to lower inflammation, reduce pain, prevent joint damage, slow down the disease and prevent complications.

Rheumatoid arthritis facts and statistics are important to understanding how RA works and progresses and apply to groups of people from where these numbers were gathered. They may also be helpful to your doctor in developing a treatment plan.

But you and your RA are unique, and these statistics only offer guidance to many possible scenarios and outcomes. They cannot tell you how you will be affected personally by RA and what your health outcomes will be.

You can improve your outcomes by practicing healthy habits and adhering to your treatment plan. Successful management of RA will enhance your quality of life, reduce pain and symptoms, and promote better emotional and mental health.

Resources

American College of Rheumatology (Prevalence Statistics)

National Institutes of Health (The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases)

Science Daily (Women with rheumatoid arthritis have significantly higher risk of mortality)

National Institutes of Health (Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: effect of different methods of case classification)

Fibromyalgia: Open Access (Fibromyalgia in the Context of Rheumatoid Arthritis: A Review)

National Institutes of Health (Racial and Ethnic Disparities in Disease Activity in Rheumatoid Arthritis Patients)

National Institutes of Health (Risk for rheumatic disease in relation to ethnicity and admixture)

Health Grove (Global Statistics: Rheumatoid Arthritis)

National Institutes of Health (Genetics of Rheumatoid Arthritis — A Comprehensive Review)

National Institutes for Health (Hospitalization Rates and Utilization among Patients with Rheumatoid Arthritis: a Population-Based Study from 1987 to 2012 in Olmsted County, Minnesota)

Arthritis Research & Therapy (Cigarette smoking and risk of rheumatoid arthritis: a dose-response meta-analysis)

Annals of Rheumatic Diseases (Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case–control study)

National Institutes of Health (Infectious causes of death in patients with rheumatoid arthritis: an autopsy study)

Arthritis Research & Therapy (Sustained biologic-free and drug-free remission in rheumatoid arthritis, where are we now?)

National Institutes of Health (Significance of Sex in Achieving Sustained Remission in the Consortium of Rheumatology Researchers of North America (CORRONA) Cohort of Rheumatoid Arthritis Patients)

National Institutes for Health (Cardiovascular complications of Rheumatoid Arthritis – Assessment, prevention and treatment)

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