Understanding Rheumatoid Arthritis in Men

Are There Really Gender Differences With Rheumatoid Arthritis?

Understanding Rheumatoid Arthritis in MenAlthough rheumatoid arthritis can be equally devastating for both sexes, it is clear that RA affects more women than men. Approximately 1.3 million US citizens suffer from RA, and women are thought to outnumber men three to one – some claim it is four to one.

Though RA is clearly more prevalent among women, there really isn’t much conclusive evidence as to why this is the case. Some doctors theorize that estrogen levels are at play, but the conclusive answer is unknown.

Men are More Apt to Ignore Their Pain

Due to the societal expectation that men suffering should ignore their pain and/or “man up,” more men seem to suffer in silence. It’s possible many more men suffer from RA but they neglect to acknowledge their pain due to the fear of social stigma or out of worry they will jeopardize their job or even their role as provider for their family.

However, this can be troublesome as RA causes the most damage to joints within the first two years. Downplaying symptoms or ignoring them can lead to major consequences for men or women who try and make other excuses for their pain.

Men may be reluctant to admit to even their doctor they are in pain. In an examination for RA, patients are often asked to reveal how much pressure on their joints hurts. Men will more often say that it hurts less than it actually does, making it more difficult to treat the illness. This is where objective testing comes in to help doctors measure the activity of the disease, such as with X-rays, scans and blood work.


Dr. Grant Louie, a rheumatologist at Johns Hopkins, warns men that they should be more vigilant and aware of their pain. If something hurts or feels off, they should notify their doctors right away. With RA, early intervention is often key to successfully managing it in the future.

Battle of the Sexes

Dr. Tuulikki Sokka published an article on the sex differences in RA in the December 2009 issue of The Rheumatologist. He noted that focusing too much on the differences between RA in men and women can affect the way we think of similarities when it comes to disease activity in men and women.

Women, he says, are often more functionally disabled than men, but he also asks that people consider the size difference and overall strength difference between men and women. This, he says, may account for some of the reasons women are seen to have RA “worse” than men do.

But, still, there are some differences that Dr. Sokka notes. “Male sex was recently shown to be a major predictor of remission in early RA. Analyses of RA differences include studies indicating higher disease activity and poorer functional status in women when compared with men,” he wrote.

“Some recent studies have also suggested that men have better responses to treatment with biologic agents than women. On the other hand, men have been shown to experience more adverse effects, particularly serious infections, during biologic treatments.

Next page: unique challenges men face.

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